Background:
@EN Phospholipase C isozymes(PLCs) play a central role in ligand-mediated signal
transduction for cellular activity such as proliferation and differentiation. However, the
biological significance of their molecules in carcinogenesis or tumor progression is not
determined precisely yet.
@ES Materials and Methods:
@EN Using PLC- 1 specific antibody, we have examined the relative contents of PLC- 1
specific antibody, we have examined the relative contents of PLC- 1 in various types of
human cancer tissue, by immunoblotting and immunohistochemistry techniques. Several
oncogene studies and DNA ploidy study were performed additionally in some tumors.
@ES Results:
@EN Most malignancy showed elevated contents of PLC- 1, especially in colorectal and
breast cancer, whereas hepatocellular carcinoma revealed decreased expression of PLC- 1,
especially in colorectal and breast cancer, whereas hepatocellular carcinoma revealed decreased
expression of PLC- 1. oncoprotein expression was correlated with PLC- expression in some
tumors. In hepatocellular carcinoma, DNA ploidy has an influence to PLC- 1 expression in
most of the cases.
@ES Conclusion:
@EN In conclusion, alteration or imbalance of the PLC- 1 mediated signal transduction may
have a significant role in the development or progression of cancer. These findings not only
have important implications for increasing our understanding of multistage carcinogenesis but
they also have an impact on strategies for diagnosis and therapy of cancers.
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